Very weird, if the kernel module is loaded, there should be the device under /dev too. From dmesg I see something suspicious:   [ 1249.869135] usbcore: registered new interface driver ch341 [ 1249.869317] usbserial: USB Serial support registered for ch341-uart [ 1249.869609] ch341 1-1.3:1.0: ch341-uart converter detected [ 1249.872306] usb 1-1.3: ch341-uart converter now attached to ttyUSB0 [ 3599.906107] input: BRLTTY 6.5 Linux Screen Driver Keyboard as /devices/virtual/input/input