I have this same issue on the Odroid N2+, I was hoping the recent updates would solve it, but it's still happening (using Focal 21.05.1 / 5.10.34). I will be switching to Buster to see if I have better luck there.
The monitor suddenly goes into powersave/suspend mode, like Arne pointed out it seems to happen shortly after switching on (within 2-5 minutes). It occurs on both my 27" Benq monitor and 5VU touchscreen both running over HDMI. The fix is simple enough, I can either turn the Benq monitor on/off to get back the connection or the 5VU will re-activate if I touch the screen.
After reacquiring/reconnecting both monitors stay on just fine after that. I've had them both running for 24-hours straight without the monitors turning off. So it seems to be something that happens once after boot.
For what it's worth, I've noticed it happens more often when I'm quickly switching to and dragging a window (for example moving Terminal to get to Firefox). Also if I double-click on the HDMI script that's in /usr/local/bin it can sometimes turn the monitor off (yes I know I'm not supposed to double-click the script, but old habits die hard).
Otherwise, I wanna say, you guys have done a great job with Armbian on the N2+, aside from that issue, it's running really smooth for me. Armbian runs my audio software better than all the other ARM distros I've tried!