It seems to be somewhat nuanced (well, at least from the perspective of someone like me that hasn't done much systemctl stuff).
I tried that command previously and it didn't work. It seems you have to plug your USB cable in between the Orange Pi and the other computer you're using *before* you disable that tty. Doing so will make sure you have the other device available (on my Mac it's /dev/tty.usbmodem1411). Once you've done that, you can then disable serial-getty@ttyGS0.service.
Then you're able to use screen (or whatever) to communicate over that connection.
If you reboot with it *disabled*, upon reboot, you can't establish the connection (/dev/tty.usbmodem1411 doesn't populate on the other host). This is where I was stuck before.
The interesting thing is that the status from "sudo systemctl status serial-getty@ttyGS0.service" shows the same either way. Also, the kernel modules is loaded in each cases.
Anyway, I'll dig around and see if I can figure out what's causing that. Thanks for the input. It pushed me in the right direction and helped me find that little inconsistency.